N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Base Information

Chemical Name:N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}
CAS No.:1240138-00-4
Molecular Formula:C₅₈H₅₀Cl₂N₄O₁₀
Molecular Weight:1033.96
Hs Code.:

N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Synonyms:

Suppliers and Price of N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

There total 10 articles about N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 1240138-00-4
N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethyl acetate / 1.5 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

2.2: 2 h / 60 °C

3.1: aluminum (III) chloride / 22 h / -5 °C

3.2: 35 - 50 °C

3.3: 18 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

5.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

6.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

7.1: triethylamine / isopropyl alcohol; acetonitrile / 5 h / 20 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; water; copper diacetate; potassium formate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethyl acetate; isopropyl alcohol; toluene; acetonitrile; 2.1: Mitsunobu reaction / 3.1: Friedel Crafts acylation / 7.1: Wittig reaction;
DOI:10.1021/op100186c

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 1240138-00-4
N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

1.2: 2 h / 60 °C

2.1: aluminum (III) chloride / 22 h / -5 °C

2.2: 35 - 50 °C

2.3: 18 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

4.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

5.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

6.1: triethylamine / isopropyl alcohol; acetonitrile / 5 h / 20 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; water; copper diacetate; potassium formate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; isopropyl alcohol; toluene; acetonitrile; 1.1: Mitsunobu reaction / 2.1: Friedel Crafts acylation / 6.1: Wittig reaction;
DOI:10.1021/op100186c

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1240138-00-4
N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

3: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

4: copper diacetate / methanol / 2.5 h / 50 - 60 °C

5: triethylamine / isopropyl alcohol; acetonitrile / 5 h / 20 °C

With oxalyl dichloride; tetrabutylammomium bromide; water; copper diacetate; potassium formate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; isopropyl alcohol; toluene; acetonitrile; 5: Wittig reaction;
DOI:10.1021/op100186c