N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

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Chemical Name:N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide
CAS No.:213823-33-7
Molecular Formula:C₄₃H₄₈N₆O₇
Molecular Weight:760.89
Hs Code.:

N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

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Suppliers and Price of N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

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Technology Process of N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

There total 9 articles about N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 213823-33-7
N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: NaH / acetonitrile

3: aq. NaOH / pyridine; methanol / Ambient temperature

4: pyridine

With sodium hydroxide; sodium hydride; In pyridine; methanol; acetonitrile;
DOI:10.1080/07328319708006111

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 213823-33-7
N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine

2: NIS / dimethylformamide

3: 60 percent / NaH / acetonitrile

4: 65 percent / NH₃ / methanol / 95 - 100 °C

5: pyridine

6: NaH / acetonitrile

7: aq. NaOH / pyridine; methanol / Ambient temperature

8: pyridine

With sodium hydroxide; N-iodo-succinimide; ammonia; sodium hydride; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/07328319708006111

Reference yield:

: 149765-16-2
N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-propionamide

: 213823-33-7
N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / NaH / acetonitrile

2: 65 percent / NH₃ / methanol / 95 - 100 °C

3: pyridine

4: NaH / acetonitrile

5: aq. NaOH / pyridine; methanol / Ambient temperature

6: pyridine

With sodium hydroxide; ammonia; sodium hydride; In pyridine; methanol; acetonitrile;
DOI:10.1080/07328319708006111