3-[2-(4-METHOXYPHENOXY)PHENYL]ACRYLIC ACID

Base Information

• Chemical Name: 3-[2-(4-METHOXYPHENOXY)PHENYL]ACRYLIC ACID
• CAS No.: 1164549-12-5
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.285
• Mol file: 1164549-12-5.mol

Synonyms:

Chemical Property of 3-[2-(4-METHOXYPHENOXY)PHENYL]ACRYLIC ACID

Chemical Property:

• Melting Point: 208-210°C
• Boiling Point: 423.4±35.0 °C(Predicted)
• PKA: 4.43±0.10(Predicted)
• Density: 1.230±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-[2-(4-Methoxyphenoxy)phenyl]acrylic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(4-METHOXYPHENOXY)PHENYL]ACRYLIC ACID

There total 1 articles about 3-[2-(4-METHOXYPHENOXY)PHENYL]ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 2-(4-methoxyphenoxy)benzaldehyde (19434-36-7) → C16H14O4 (1164549-12-5)

Guidance literature:

With piperidine; pyridine; at 70 - 80 ℃;

DOI:10.1002/cmdc.201800238

Reference yield:

O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + C16H14O4 (1164549-12-5) → C21H23NO5

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/cmdc.201800238

Reference yield:

C16H14O4 (1164549-12-5) → (2E)-N-hydroxy-3-[2-(4-methoxyphenoxy)phenyl]-2-propenamide (1446253-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: hydrogenchloride / methanol; water / 20 - 70 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;

DOI:10.1002/cmdc.201800238

upstream raw materials:

malonic acid

2-(4-methoxyphenoxy)benzaldehyde

Downstream raw materials:

(2E)-N-hydroxy-3-[2-(4-methoxyphenoxy)phenyl]-2-propenamide

Refernces