(1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

Base Information

• Chemical Name: (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one
• CAS No.: 124378-95-6
• Molecular Formula: C₇H₅NO₃S*C₂₀H₂₅NO
• Molecular Weight: 478.612

Synonyms:

Chemical Property of (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one

There total 2 articles about (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,7S)-3,7-Dimethyl-1-phenyl-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine; compound with perchloric acid (124439-12-9,101399-21-7) → (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (124378-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 1 N NaOH 2) MCPBA / 1) ethyl acetate 2) 24h

2: ethyl acetate; methanol; hexane

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In methanol; hexane; ethyl acetate;

DOI:10.1021/jo00289a064

Reference yield:

<1α,3α,7β>-2,3,4,5,6,7-hexahydro-3,7-dimethyl-1-phenyl-1H-3-benzazonine N-oxide (124342-87-6) + saccharin (81-07-2) → (1R,3S,7S)-3,7-Dimethyl-1-phenyl-1,2,4,5,6,7-hexahydro-benzo[d]azonine 3-oxide; compound with 1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (124378-95-6)

Guidance literature:

In methanol; hexane; ethyl acetate; Yield given;

DOI:10.1021/jo00289a064

upstream raw materials:

<1α,3α,7β>-2,3,4,5,6,7-hexahydro-3,7-dimethyl-1-phenyl-1H-3-benzazonine N-oxide

saccharin

(1R,7S)-3,7-Dimethyl-1-phenyl-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine; compound with perchloric acid

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