N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
CAS No.:1394165-71-9
Molecular Formula:C₄₁H₃₇F₃N₄O₅
Molecular Weight:722.764
Hs Code.:

N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Synonyms:

Suppliers and Price of N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

There total 18 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: C₁₆H₈ClF₂NO₂

: 1394165-71-9
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h; Cooling with ice;
DOI:10.1002/ardp.201300029

Reference yield:

: C₁₈H₁₄F₃NO₃

: 1394165-71-9
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 50 °C

2: sodium hydroxide / ethanol / 5 h / 20 °C

3: thionyl chloride / toluene / 5 h / 80 °C

4: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.201300029

Reference yield:

: 1436417-99-0
4-chloro-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)-quinoline

: 1394165-71-9
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: chlorobenzene / 30 h / 140 °C

2: iron; ammonium chloride / ethanol / 5 h / Reflux

3: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; chlorobenzene;
DOI:10.1002/ardp.201300029