FMoc-Val-Cit-PAB-MMAE

Base Information

• Chemical Name: FMoc-Val-Cit-PAB-MMAE
• CAS No.: 1350456-56-2
• Molecular Formula: C₇₃H₁₀₄N₁₀O₁₄
• Molecular Weight: 1345.69
• Mol file: 1350456-56-2.mol

Synonyms:

Chemical Property of FMoc-Val-Cit-PAB-MMAE

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-Val-Cit-PAB-MMAE 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Fmoc-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate containing a cleavable Val-Cit peptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.
• Uses: Fmoc-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate containing a cleavable Val-Cit peptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Technology Process of FMoc-Val-Cit-PAB-MMAE

There total 3 articles about FMoc-Val-Cit-PAB-MMAE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.9%

[3H]-Vedotin (474645-27-7,1057314-02-9) + (9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate (863971-53-3) → Fmoc-Val-Cit-PABC-MMAE (1350456-56-2)

Guidance literature:

With pyridine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 30h;

DOI:10.1039/c6ob01751g

Reference yield: 37.5%

C41H43N7O11 + C39H67N5O7 → C73H104N10O14 (1350456-56-2)

Guidance literature:

C₄₁H₄₃N₇O₁₁; C₃₉H₆₇N₅O₇; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

With pyridine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 35.5h;

Reference yield:

(9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate (863971-53-3) + N-phenyl maleimide monomethyl-auristatin-E (1057314-02-9) → C73H104N10O14 (1350456-56-2)

Guidance literature:

With pyridine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

[3H]-Vedotin

(9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate

N-phenyl maleimide monomethyl-auristatin-E

Refernces

• 1、 -. "SELF-STABILIZING LINKER CONJUGATES". Paragraph 0551-0553. . Retrieved 2021/10/02.
• 2、 -. "LINKERS AND CONJUGATES". Page/Page column 48-49. . Retrieved 2020/02/23.