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863971-53-3

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  • FMOC-VAL-CIT-PAB-PNP (9-FLUORENYLMETHYLOXYCARBONYL-VALYL-CITRULLYL-(4-AMINOBENZYL)-(4-NITROPHENYL)CARBONATE)

    Cas No: 863971-53-3

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863971-53-3 Usage

Description

Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload.

Biological Activity

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).

Check Digit Verification of cas no

The CAS Registry Mumber 863971-53-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,3,9,7 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 863971-53:
(8*8)+(7*6)+(6*3)+(5*9)+(4*7)+(3*1)+(2*5)+(1*3)=213
213 % 10 = 3
So 863971-53-3 is a valid CAS Registry Number.

863971-53-3Relevant articles and documents

CANCER VACCINE

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Page/Page column 50, (2021/03/13)

The invention relates to a combination of a TLR-9 agonist and a conjugate of Formula (I) or pharmaceutically acceptable salt thereof. (Formula (I))

GLYCOPEPTIDE VACCINE

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Page/Page column 50, (2020/11/30)

The present invention generally relates to a glycopeptide conjugate compound of Formula (I):, as described herein, compositions comprising the conjugate compound and to the use of such a compound to as a vaccine.

LINKERS AND CONJUGATES

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, (2020/02/23)

A conjugate comprising a protein or a peptide, a linker and an active agent, wherein the linker comprises the moiety of formula (III): (III) wherein two of A1, A2 and A3 are N and the other of A1, A2

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