Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R,S)]-

Base Information

Chemical Name:Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]-
CAS No.:118528-02-2
Molecular Formula:C₁₈H₃₀O₄Si
Molecular Weight:338.519
Hs Code.:
DSSTox Substance ID:DTXSID001114535

Synonyms:DTXSID001114535;118528-02-2;Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]-

Suppliers and Price of Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]-

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:338.19133597
Heavy Atom Count:23
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)CC(CC(CO)[Si](C)(C)C)CC(=O)OC
Isomeric SMILES:COC1=CC=CC(=C1)C[C@@H](C[C@@H](CO)[Si](C)(C)C)CC(=O)OC

Technology Process of Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]-

There total 5 articles about Benzenebutanoic acid, beta-[3-hydroxy-2-(trimethylsilyl)propyl]-3-methoxy-, methyl ester, [S-(R*,S*)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 67-56-1
methanol

: 118626-51-0
(4R,6S)-4-(3-Methoxy-benzyl)-6-trimethylsilanyl-oxepan-2-one

: 118528-02-2
(3R,5S)-6-Hydroxy-3-(3-methoxy-benzyl)-5-trimethylsilanyl-hexanoic acid methyl ester

Guidance literature:: With sodium methylate; for 1h; Ambient temperature;
DOI:10.1246/cl.1988.805

Reference yield:

: 56917-71-6
5-trimethylsilyl-2-cyclohexanone

: 118528-02-2
(3R,5S)-6-Hydroxy-3-(3-methoxy-benzyl)-5-trimethylsilanyl-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CuBr, Me₂S, HMPA, TMSCl / tetrahydrofuran / -100 °C

2: 89 percent / m-CPBA

3: MeONa / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; dimethylsulfide; sodium methylate; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide; In tetrahydrofuran;
DOI:10.1246/cl.1988.805

Reference yield:

: 118527-74-5,118527-77-8,118626-49-6,118626-50-9,122044-79-5,122044-88-6
trans-3-(m-methoxy-benzyl)-5-(trimethylsilyl)-cyclohexanone

: 118528-02-2
(3R,5S)-6-Hydroxy-3-(3-methoxy-benzyl)-5-trimethylsilanyl-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / m-CPBA

2: MeONa / Ambient temperature

With sodium methylate; 3-chloro-benzenecarboperoxoic acid;
DOI:10.1246/cl.1988.805