C₂₃H₃₃⁽²⁾H₂N₃O₆

Base Information

• Chemical Name: C₂₃H₃₃⁽²⁾H₂N₃O₆
• CAS No.: 84759-58-0
• Molecular Formula: C₂₃H₃₅N₃O₆
• Molecular Weight: 451.532
• Mol file: 84759-58-0.mol

Synonyms:

Chemical Property of C₂₃H₃₃⁽²⁾H₂N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₃₃⁽²⁾H₂N₃O₆

There total 18 articles about C₂₃H₃₃⁽²⁾H₂N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tBOC-Gly-ΔPhe-(S)-Leu-OMe (90761-06-1) → C23H33(2)H2N3O6 (84759-58-0,84759-59-1) + C23H33(2)H2N3O6 (84759-58-0,84759-59-1)

Guidance literature:

With deuterium; <(Ph-CAPP)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; for 18h; under 7600 Torr; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

tBOC-Gly-ΔPhe-(S)-Leu-OMe (90761-06-1) → C23H33(2)H2N3O6 (84759-58-0,84759-59-1) + C23H33(2)H2N3O6 (84759-58-0,84759-59-1)

Guidance literature:

With deuterium; <(Ph-CAPP)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; for 18h; under 7600 Torr; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

BOC-glycine (4530-20-5) → C23H33(2)H2N3O6 (84759-58-0,84759-59-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide

2: 1N NaOH / H₂O; methanol

3: NaOAc, Ac₂O

4: Et₃N / CHCl₃

5: dideuterium / <(diPAMP)Rh(norbornadiene)>⁽¹⁺⁾*ClO₄^(1-) / ethanol / 18 h / 40 °C / 7600 Torr

With 4-methyl-morpholine; sodium hydroxide; sodium acetate; acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; deuterium; <(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-); In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82412-1

upstream raw materials:

^tBOC-Gly-ΔPhe-(S)-Leu-OMe

methyl (L)-leucinate hydrochloride

Boc-Gly-Δ^ZPhe azlactone

BOC-glycine