Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester

Base Information

• Chemical Name: Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester
• CAS No.: 93644-77-0
• Molecular Formula: C₂₁H₂₀N₄O₅S
• Molecular Weight: 440.48
• Mol file: 93644-77-0.mol

Synonyms:

Chemical Property of Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester

There total 1 articles about Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

thiobenzoic acid potassium salt (28170-13-0) + mitomycin C (50-07-7) → Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester (93644-77-0) + C27H23N3O4S2 (93604-43-4) + Thiobenzoic acid S-((1R,2S)-7-amino-2-benzoylamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester (93712-79-9) + Thiobenzoic acid S-((1S,2S)-7-amino-2-benzoylamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester (93604-42-3)

Guidance literature:

With sodium dithionite; oxygen; In water; for 0.166667h; Further byproducts given; Ambient temperature; ph 6;

DOI:10.1021/jo00203a002

Reference yield: 13.4%

chloroformic acid ethyl ester (541-41-3) + Thiobenzoic acid S-((1R,2S)-2,7-diamino-9-carbamoyloxymethyl-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester (93644-77-0) → Thiobenzoic acid S-((1R,2S)-7-amino-9-carbamoyloxymethyl-2-ethoxycarbonylamino-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester (93604-45-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/jo00203a002

upstream raw materials:

thiobenzoic acid potassium salt

mitomycin C

Downstream raw materials:

Thiobenzoic acid S-((1R,2S)-7-amino-9-carbamoyloxymethyl-2-ethoxycarbonylamino-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl) ester