N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide

Base Information

• Chemical Name: N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide
• CAS No.: 896719-73-6
• Molecular Formula: C₅₇H₆₉N₉O₆Si₂
• Molecular Weight: 1032.4
• Mol file: 896719-73-6.mol

Synonyms:

Chemical Property of N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide

There total 2 articles about N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C70H81N9O6Si2 (896719-71-4) → N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide (896719-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichloroacetic acid / CH₂Cl₂; methanol

2: pyridine / 0 °C

With pyridine; trichloroacetic acid; In methanol; dichloromethane;

DOI:10.1021/tx050296s

Reference yield:

N8-benzyl-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-72-5) + Phenoxyacetyl chloride (701-99-5) → N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide (896719-73-6)

Guidance literature:

With pyridine; at 0 ℃;

DOI:10.1021/tx050296s

Reference yield:

N-{8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-2-yl}-2-phenoxy-acetamide (896719-73-6) → N-(O6-benzyl-N2-phenoxyacetyl-2'-deoxyguanosin-8-yl)-N-benzyl-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (896719-74-7)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; for 24h;

DOI:10.1021/tx050296s

upstream raw materials:

N⁸-benzyl-6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

Phenoxyacetyl chloride

C₇₀H₈₁N₉O₆Si₂

Downstream raw materials:

N-(O⁶-benzyl-N²-phenoxyacetyl-2'-deoxyguanosin-8-yl)-N-benzyl-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

N-(8-[benzyl-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-amino]-6-benzyloxy-9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-2-yl)-2-phenoxy-acetamide