2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide

Base Information

• Chemical Name: 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide
• CAS No.: 77181-72-7
• Molecular Formula: C₃₀H₃₉N₅O₉
• Molecular Weight: 613.668
• Mol file: 77181-72-7.mol

Synonyms:

Chemical Property of 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide

There total 3 articles about 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3'-O-isopropylideneuridine (362-43-6) → 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide (77181-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / potassium carbonate / dimethylformamide / 72 h / 70 °C

2: 76 percent / 0.2 N aq. HCl / dioxane / 3.5 h / Ambient temperature

3: methanol; CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2',3'-O-ispropylidene 3-(3,3-diethoxypropyl)uridine (77195-89-2) → 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide (77181-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / 0.2 N aq. HCl / dioxane / 3.5 h / Ambient temperature

2: methanol; CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

1-isocyanocyclohexene (1121-57-9) + 1-(1-oxidopyridin-2-yl)methanamine (50921-45-4) + acetic acid (64-19-7,77671-22-8) + 2',3'-O-ispropylidene 3-(2-formylethyl)uridine (77181-71-6) → 2-[Acetyl-(1-oxy-pyridin-2-ylmethyl)-amino]-N-cyclohex-1-enyl-4-[3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyramide (77181-72-7)

Guidance literature:

In methanol; dichloromethane; for 24h; Ambient temperature;

upstream raw materials:

1-isocyanocyclohexene

1-(1-oxidopyridin-2-yl)methanamine

acetic acid

2',3'-O-ispropylidene 3-(2-formylethyl)uridine