4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine

Base Information

Chemical Name:4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine
CAS No.:220394-98-9
Molecular Formula:C₂₁H₃₂N₂O₄
Molecular Weight:376.496
Hs Code.:
DSSTox Substance ID:DTXSID701131489

Synonyms:SCHEMBL7134804;HBPLAUGNQOCDSD-UHFFFAOYSA-N;DTXSID701131489;4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine;220394-98-9;1,1-Dimethylethyl 4-[[(phenylmethoxy)carbonyl]propylamino]-1-piperidinecarboxylate

Suppliers and Price of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:376.23620751
Heavy Atom Count:27
Complexity:475

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCN(C1CCN(CC1)C(=O)OC(C)(C)C)C(=O)OCC2=CC=CC=C2

Technology Process of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine

There total 6 articles about 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220394-97-8
4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine

: 220394-98-9
4-(benzyloxycarbonyl-propyl-amino)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(01)00492-9

Reference yield:

: 90633-18-4
4-bromo-1H-piperidine

: 220394-98-9
4-(benzyloxycarbonyl-propyl-amino)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / CH₂Cl₂

2: NaN₃ / dimethylformamide / 20 °C

3: H₂ / 10 percent Pd/C / methanol / 2068.59 Torr

4: DIPEA / CH₂Cl₂ / 20 °C

5: NaH / dimethylformamide / 20 °C

With sodium azide; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00492-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 220394-98-9
4-(benzyloxycarbonyl-propyl-amino)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / CH₂Cl₂

2: NaN₃ / dimethylformamide / 20 °C

3: H₂ / 10 percent Pd/C / methanol / 2068.59 Torr

4: DIPEA / CH₂Cl₂ / 20 °C

5: NaH / dimethylformamide / 20 °C

With sodium azide; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00492-9