8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE

Base Information

• Chemical Name: 8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE
• CAS No.: 1218-52-6
• Molecular Formula: C15H9BrO2
• Molecular Weight: 301.139
• Hs Code.: 2914700090
• Mol file: 1218-52-6.mol

Synonyms:8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE;8-Brom-flavon;8-bromoflavone;8-bromo-2-phenyl-chromen-4-one;8-BROMO-2-PHENYL-4H-1-BENZOPYRAN-4-ONE;

Chemical Property of 8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE

Chemical Property:

• PSA: 30.21000
• LogP: 4.22250

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-2-phenyl-4h-chromen-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE

There total 9 articles about 8-BROMO-2-PHENYL-4H-CHROMEN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3'-bromo-2'-hydroxychalcone (68560-81-6) → 8-bromo-2-phenyl-4H-chromen-4-one (1218-52-6)

Guidance literature:

With iodine; In dimethyl sulfoxide; for 0.25h; Reflux;

DOI:10.1055/s-0035-1560325

Reference yield: 75.0%

3’-bromo-2’-hydroxylacetophenone (1836-05-1) + benzoyl chloride (98-88-4) → 8-bromo-2-phenyl-4H-chromen-4-one (1218-52-6)

Guidance literature:

3’-bromo-2’-hydroxylacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -20 ℃; for 2.5h;

benzoyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

With sulfuric acid; acetic acid; In tetrahydrofuran; at 120 ℃; for 0.0833333h;

DOI:10.1039/b610734f

Reference yield: 73.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) + 2-hydroxy-3-bromobenzaldehyde (1829-34-1) → 8-bromo-2-phenyl-4H-chromen-4-one (1218-52-6)

Guidance literature:

2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one; 2-hydroxy-3-bromobenzaldehyde; With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In 1,2-dichloro-ethane; at 100 ℃; for 6h; Sealed tube; Inert atmosphere;

With sulfuric acid; acetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1177/1747519819867230

upstream raw materials:

3’-bromo-2’-hydroxylacetophenone

benzoyl chloride

2-hydroxybromobenzene

o-bromophenyl acetate

Downstream raw materials:

2,8-diphenyl-chromen-4-one

6,8''-biflavone

7,8''-biflavone

8,8''-biflavone