1836-05-1

Basic information

• Product Name: 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE
• Synonyms: 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE;Ethanone, 1-(3-broMo-2-hydroxyphenyl)-;2-Acetyl-6-broMophenol;1-(3-Bromo-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-bromophenol;3'-Bromo-2'-hydroxyacetophenone 97%;3'-Bromo-2'-hydroxyacetophenone;3'-Bromo-2'-hydroxyacetophenone97%
• CAS NO: 1836-05-1
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.04
• Mol File: 1836-05-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 33°C
• Boiling Point: 252.331°C at 760 mmHg
• Flash Point: 106.406°C
• Appearance: /
• Density: 1.586g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.63±0.10(Predicted)
• CAS DataBase Reference: 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE(1836-05-1)
• EPA Substance Registry System: 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE(1836-05-1)

Safety Data

• Hazardous Substances Data: 1836-05-1(Hazardous Substances Data)

Usage

Preparation

Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (49%).

InChI:InChI=1/C8H7BrO2/c1-5(10)6-3-2-4-7(9)8(6)11/h2-4,11H,1H3

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 75-36-5 acetyl chloride 
• 1829-37-4 o-bromophenyl acetate 
• 118-93-4 o-hydroxyacetophenone 
• 70977-72-9 3'-Amino-2'-hydroxyacetophenone 

Downstream Products

• 1774-70-5 2,2'-Dihydroxy-3'-brom-chalkon 
• 1911-56-4 2'-Hydroxy-3',4-dibrom-chalkon 
• 1260485-22-0 8-bromo-4H-chromen-4-one 
• 267651-23-0 1-(3-bromo-2-methoxyphenyl)ethan-1-one 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 42524-23-2 2-Hydroxy-3-bromacetophenonoxim 
• 66033-75-8 7-Brom-3-methyl-1,2-benzisoxazol 
• 1774-58-9 2,2'-Dihydroxy-3',3,5-tribrom-chalkon 
• 68560-81-6 3'-bromo-2'-hydroxychalcone 

Relevant articles and documents

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.

Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans

Intramolecular addition of an O-methyl C(sp3)?H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp3)?H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.).

Regioselective monobromination of aromatics via a halogen bond acceptor-donor interaction of catalytic thioamide and N-bromosuccinimide

Regioselective monobromination of various aromatics was achieved at room temperature using N-bromosuccinimide and 5 mol% of thioamides in acetonitrile. With thiourea as catalyst, activated aromatics, such as anisole, acetanilide, benzamide and phenol analogues containing electron donating or withdrawing groups, were brominated with high regioselectivity. Room temperature brominations of weakly activated aromatics and deactivated 9-fluorenone were accomplished by 5 mol% thioacetamide, higher substrates concentrations and longer reaction times. A backbonding of the bromine lone pairs with the π*of C[dbnd]S group and a halogen bond between the halogen bond donor bromine and the halogen bond acceptor sulfur of the thioamide are thought to be the principal interactions and cause of N-bromosuccinimide activation.