C₁₁H₈BrFN₄

Base Information

• Chemical Name: C₁₁H₈BrFN₄
• CAS No.: 1333991-70-0
• Molecular Formula: C₁₁H₈BrFN₄
• Molecular Weight: 295.114
• Mol file: 1333991-70-0.mol

Synonyms:

Chemical Property of C₁₁H₈BrFN₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₈BrFN₄

There total 1 articles about C₁₁H₈BrFN₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrimidinylhydrazine (7504-94-1) + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → C11H8BrFN4 (1333991-70-0)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2011.07.034

Reference yield:

C11H8BrFN4 (1333991-70-0) → C11H6BrFN4 (1333991-79-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2011.07.034

Reference yield:

C11H8BrFN4 (1333991-70-0) → C23H18F2N6O3 (1333991-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1: [bis(acetoxy)iodo]benzene / dichloromethane / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; potassium acetate; potassium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile; 2: Miyaura borylation / 3: Suzuki coupling reaction;

DOI:10.1016/j.bmcl.2011.07.034

upstream raw materials:

2-pyrimidinylhydrazine

4-bromo-2-fluorobenzaldehyde

Downstream raw materials:

C₂₃H₁₈F₂N₆O₃

C₁₁H₆BrFN₄

C₁₇H₁₈BFN₄O₂