N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

Base Information

Chemical Name:N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide
CAS No.:475062-09-0
Molecular Formula:C₃₂H₃₅N₉O₄S
Molecular Weight:641.754
Hs Code.:

N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

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Chemical Property of N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

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Technology Process of N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

There total 1 articles about N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 475062-07-8
N-(4-tert-butyl-1,3-thiazol-2-yl)-2-hydroxy-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

: 198976-43-1
(R)-piperidin-3-ol hydrochloride

: 475062-09-0
N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

Guidance literature:: N-(4-tert-butyl-1,3-thiazol-2-yl)-2-hydroxy-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide; With N-ethyl-N,N-diisopropylamine; chlorophosphoric acid diphenyl ester; In N,N-dimethyl-formamide; acetonitrile; at 0 ℃; for 0.833333h;

(R)-piperidin-3-ol hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 80 ℃; for 1h; Further stages.;
DOI:10.1016/j.bmc.2007.07.039

Reference yield:

: 475062-09-0
N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

: 3019-71-4
Trichloroacetyl isocyanate

: (CH₃)3C₄H₂SN₂COC₈H₃N₂OCHCHCN₄CH₂C₆H₄OCH₃NC₅H₉OCONHCOCCl₃

Guidance literature:: In ethyl acetate; at 0 ℃; for 0.75h;
DOI:10.1016/j.bmc.2007.07.039

Reference yield:

: 475062-09-0
N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide

: 64269-79-0
Carbonyldiimidazole

: 108-00-9
N,N-dimethylethylenediamine

: 957471-88-4
(3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate

Guidance literature:: N-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(3R)-3-hydroxypiperidin-1-yl]-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide; Carbonyldiimidazole; In dichloromethane; for 3h;

N,N-dimethylethylenediamine; In dichloromethane; for 68h; Further stages.;
DOI:10.1016/j.bmc.2007.07.039