4-Nitrophenyl phenylacetate

Base Information

• Chemical Name: 4-Nitrophenyl phenylacetate
• CAS No.: 1223-44-5
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.246
• Hs Code.: 2916399090
• Mol file: 1223-44-5.mol

Synonyms:Phenylessigsaeure-<4-nitro-phenylester>;p-nitrophenyl 2-phenylacetate;4-Nitrophenyl-phenylacetat;Phenylacetic acid,4-nitrophenyl ester;Phenylessigsaeure-;4-nitrophenyl phenylacetate;p-nitrophenyl phenylacetate;

Chemical Property of 4-Nitrophenyl phenylacetate

Chemical Property:

• PSA: 72.12000
• LogP: 3.26610

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitrophenyl phenylacetate

There total 4 articles about 4-Nitrophenyl phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenylacetic acid (103-82-2) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 4-nitrophenyl 2-phenylacetate (1223-44-5)

Guidance literature:

With 3-(5-nitro-2-oxo-1,2-dihydro-1-pyridyl)-1,2-benzisothiazole 1,1,-dioxide; triethylamine; In dichloromethane; -10 deg C -> r.t., overnight;

DOI:10.1246/cl.1980.1161

Reference yield: 70.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + phenylacetyl chloride (103-80-0) → 4-nitrophenyl 2-phenylacetate (1223-44-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c9ob00703b

Reference yield:

phenylacetic acid (103-82-2) → 4-nitrophenyl 2-phenylacetate (1223-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ol300676w

upstream raw materials:

4-nitro-phenol

phenylacetyl chloride

phenylacetic acid

Downstream raw materials:

isobutyric acid (2R,3S,4R,5R)-2-azido-3,4-dihydroxy-5-[2-oxo-4-(2-phenoxyacetylamino)-2H-pyrimidin-1-yl]-tetrahydrofuran-2-ylmethyl ester

(3S,4S)-3,6-diphenyl-4-(p-tolyl)-1-tosyl-3,4-dihydropyridin-2(1H)-one

(3S,4S)-3,6-diphenyl-4-(thiophen-2-yl)-1-tosyl-3,4-dihydropyridin-2(1H)-one

(3R,4R)-6-(4-chlorophenyl)-3,4-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one