7-(4'-chlorobenzylamino)-1-isoquinolinamine

Base Information

Chemical Name:7-(4'-chlorobenzylamino)-1-isoquinolinamine
CAS No.:943960-90-5
Molecular Formula:C₁₆H₁₄ClN₃
Molecular Weight:283.76
Hs Code.:

Synonyms:

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Chemical Property of 7-(4'-chlorobenzylamino)-1-isoquinolinamine

Chemical Property:

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Technology Process of 7-(4'-chlorobenzylamino)-1-isoquinolinamine

There total 8 articles about 7-(4'-chlorobenzylamino)-1-isoquinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244219-96-3
1,7-isoquinolinediamine

: 104-88-1
4-chlorobenzaldehyde

: 943960-90-5
7-(4'-chlorobenzylamino)-1-isoquinolinamine

Guidance literature:: 1,7-isoquinolinediamine; 4-chlorobenzaldehyde; In acetic acid; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In tetrahydrofuran; acetic acid; for 3h; Further stages.;
DOI:10.1002/jhet.5570440319

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 943960-90-5
7-(4'-chlorobenzylamino)-1-isoquinolinamine

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; potassium nitrate / water

2: hydrogenchloride / ethanol

3: potassiuim nitrosodisulfonate; sodium carbonate / water

4: 3-chloro-benzenecarboperoxoic acid

5: p-toluenesulfonyl chloride / pyridine

7: 10% palladium on activated charcoal; hydrogen

8: sodium cyanoborohydride

With hydrogenchloride; potassiuim nitrosodisulfonate; sulfuric acid; 10% palladium on activated charcoal; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium nitrate; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In pyridine; ethanol; water;
DOI:10.1016/j.bmcl.2010.11.099

Reference yield:

: 42923-79-5
7-nitro-1,2,3,4-tetrahydroisoquinoline

: 943960-90-5
7-(4'-chlorobenzylamino)-1-isoquinolinamine

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / ethanol

2: potassiuim nitrosodisulfonate; sodium carbonate / water

3: 3-chloro-benzenecarboperoxoic acid

4: p-toluenesulfonyl chloride / pyridine

6: 10% palladium on activated charcoal; hydrogen

7: sodium cyanoborohydride

With hydrogenchloride; potassiuim nitrosodisulfonate; 10% palladium on activated charcoal; hydrogen; sodium cyanoborohydride; sodium carbonate; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In pyridine; ethanol; water;
DOI:10.1016/j.bmcl.2010.11.099