C₂₁H₁₉ClNO₄PS

Base Information

• Chemical Name: C₂₁H₁₉ClNO₄PS
• CAS No.: 1421840-59-6
• Molecular Formula: C₂₁H₁₉ClNO₄PS
• Molecular Weight: 447.879
• Mol file: 1421840-59-6.mol

Synonyms:

Chemical Property of C₂₁H₁₉ClNO₄PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₉ClNO₄PS

There total 4 articles about C₂₁H₁₉ClNO₄PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) + (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide (1421840-44-9) → C21H19ClNO4PS (1421840-45-0) + C21H19ClNO4PS (1421840-59-6)

Guidance literature:

With 3,5-Lutidine; In dichloromethane; at -10 - 20 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ja312352p

Reference yield:

C16H14ClNO4S → C21H19ClNO4PS (1421840-45-0) + C21H19ClNO4PS (1421840-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / 60 °C / Inert atmosphere

1.2: 20 °C / pH 4 / Inert atmosphere

2.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

With 3,5-Lutidine; lithium hydroxide; In dichloromethane;

DOI:10.1021/ja312352p

Reference yield:

(R)-2-(1-aminoethyl)-4-chlorophenol (1228571-53-6) → C21H19ClNO4PS (1421840-45-0) + C21H19ClNO4PS (1421840-59-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethyl acetate / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: lithium hydroxide / 60 °C / Inert atmosphere

3.2: 20 °C / pH 4 / Inert atmosphere

4.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

With 3,5-Lutidine; sodium hydride; lithium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/ja312352p

upstream raw materials:

(R)-2-(1-aminoethyl)-4-chlorophenol

(R)-6-chloro-4-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

P,P-dichlorophenylphosphine oxide

(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide