MK 8825

Base Information

Chemical Name:MK 8825
CAS No.:1380887-60-4
Molecular Formula:C₃₁H₃₀F₂N₆O₃
Molecular Weight:572.614
Hs Code.:

Synonyms:

Suppliers and Price of MK 8825

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of MK 8825

Chemical Property:

Boiling Point:822.2±65.0 °C(Predicted)
Density:1.46±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of MK 8825

There total 5 articles about MK 8825 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059186-43-4
(6S)-3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

: 1263291-88-8
[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

: 1380887-60-4
MK 8825

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ml400199p

Reference yield:

: 321318-29-0,444643-16-7,771465-40-8
1-(3,5-difluorophenyl)ethylamine

: 1380887-60-4
MK 8825

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: acetic acid / methanol / 0.5 h / 20 °C

4.2: 0.5 h / pH 5

5.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

6.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

7.2: 0 - 20 °C

8.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 18 h / 20 °C

9.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; water; sodium hydride; acetic acid; HATU; lithium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400199p

Reference yield:

: 957122-13-3
di-tert-butyl [1-(3,5-difluorophenyl)ethyl]imidodicarbonate

: 1380887-60-4
MK 8825

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3.1: acetic acid / methanol / 0.5 h / 20 °C

3.2: 0.5 h / pH 5

4.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

5.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

6.2: 0 - 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 18 h / 20 °C

8.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; water; sodium hydride; acetic acid; HATU; lithium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400199p