methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

Base Information

Chemical Name:methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate
CAS No.:1189569-74-1
Molecular Formula:C₂₁H₃₀F₂N₂O₄
Molecular Weight:412.477
Hs Code.:

Synonyms:methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

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Chemical Property of methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

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Technology Process of methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

There total 8 articles about methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 78388-61-1
cycloleucine methyl ester

: 1189569-74-1
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

Guidance literature:: tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate; cycloleucine methyl ester; With acetic acid; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; acetic acid; for 0.5h; pH=5;
DOI:10.1021/ml400199p

Reference yield:

: 546-68-9
titanium(IV) isopropylate

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 60421-23-0
cycloleucine methyl ester hydrochloride

: 1189569-74-1
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

: 1189569-75-2
isopropyl 1-({2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}amino)cyclopentane-1-carboxylate

Guidance literature:: titanium(IV) isopropylate; tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate; cycloleucine methyl ester hydrochloride; at 20 ℃; for 1.5h;

With sodium cyanoborohydride; acetic acid; In methanol; Cooling;

Reference yield:

: 957122-13-3
di-tert-butyl [1-(3,5-difluorophenyl)ethyl]imidodicarbonate

: 1189569-74-1
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3.1: acetic acid / methanol / 0.5 h / 20 °C

3.2: 0.5 h / pH 5

With lithium aluminium tetrahydride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ml400199p