[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

Base Information

Chemical Name:[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid
CAS No.:1263291-88-8
Molecular Formula:C₁₇H₂₀F₂N₂O₃
Molecular Weight:338.354
Hs Code.:

Synonyms:[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

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Chemical Property of [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

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Technology Process of [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

There total 5 articles about [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1448055-86-4
ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

: 1263291-88-8
[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;
DOI:10.1021/ml400199p

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 1263291-88-8
[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 0.5 h / pH 5

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

3.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

4.2: 0 - 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 18 h / 20 °C

With hydrogenchloride; water; sodium hydride; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; ethyl acetate; mineral oil;
DOI:10.1021/ml400199p

Reference yield:

: 957122-14-4
tert-butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate

: 1263291-88-8
[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C

2.2: 0.5 h / pH 5

3.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

4.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

5.2: 0 - 20 °C

6.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; water; sodium hydride; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; ethyl acetate; mineral oil;
DOI:10.1021/ml400199p