Technology Process of (9-Benzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-acetaldehyde
There total 6 articles about (9-Benzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-acetaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) acetic acid, 3 Angstroem molecular sieves, 2.) NaBH3CN / 1.) ethanol, 1 h, 2.) ethanol, RT, 2 d
2: triethylamine / CH2Cl2
3: conc. sulfuric acid / diethyl ether / 3 h
4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
With
sodium periodate; osmium(VIII) oxide; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine;
In
diethyl ether; dichloromethane;
DOI:10.1021/jm00001a014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl chloride, N,N-dimethylformamide / CH2Cl2 / 1 h
2: triethylamine / CH2Cl2
3: conc. sulfuric acid / diethyl ether / 3 h
4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
With
sodium periodate; osmium(VIII) oxide; oxalyl dichloride; sulfuric acid; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide;
In
diethyl ether; dichloromethane;
DOI:10.1021/jm00001a014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / CH2Cl2
2: conc. sulfuric acid / diethyl ether / 3 h
3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) TF, H2O, overnight, 2.) ethanol, H2O, 2 h
With
sodium periodate; osmium(VIII) oxide; sulfuric acid; 4-methylmorpholine N-oxide; triethylamine;
In
diethyl ether; dichloromethane;
DOI:10.1021/jm00001a014
