3-Benzoyloxytetrahydrofuran

Base Information

• Chemical Name: 3-Benzoyloxytetrahydrofuran
• CAS No.: 131076-15-8
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 131076-15-8.mol

Synonyms:

Chemical Property of 3-Benzoyloxytetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzoyloxytetrahydrofuran

There total 4 articles about 3-Benzoyloxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

D,L-1,2,4-butanetriol (3068-00-6,6810-31-7) + orthobenzoic acid trimethyl ester (707-07-3) → 3-Benzoyloxytetrahydrofuran (131076-15-8,79677-01-3)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 82.0%

3-Hydroxytetrahydrofuran (453-20-3,84921-89-1,864447-89-2) + benzoyl chloride (98-88-4) → 3-Benzoyloxytetrahydrofuran (131076-15-8,79677-01-3)

Guidance literature:

With pyridine; at 10 ℃; for 10h;

Reference yield: 46.0%

3-butenyl benzoate (18203-32-2) → 3-Benzoyloxytetrahydrofuran (131076-15-8,79677-01-3)

Guidance literature:

With 4-tolyl iodide; pyridine hydrogenfluoride; Selectfluor; triethylamine tris(hydrogen fluoride); In 1,2-dichloro-ethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b01172

upstream raw materials:

3-Hydroxytetrahydrofuran

benzoyl chloride

D,L-1,2,4-butanetriol

orthobenzoic acid trimethyl ester

Downstream raw materials:

D,L-1,2,4-butanetriol

Benzoic acid 2,4-dihydroxy-butyl ester

Benzoic acid 3-hydroxy-1-hydroxymethyl-propyl ester

cis-<4-benzoxytetrahydro-2-furyl>-5-fluorouracil