18203-32-2

Upstream product

• 70388-33-9 4-benzyloxybut-1-ene 
• 142260-70-6 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one 
• 930-68-7 cyclohexenone 
• 94-36-0 dibenzoyl peroxide 
• 627-27-0 homoalylic alcohol 
• 65-85-0 benzoic acid 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 2867-66-5 1-benzoyloxy-3-bromobutane 
• 100-39-0 benzyl bromide 
• 245408-81-5 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone 
• 93-97-0 benzoic acid anhydride 
• 98-88-4 benzoyl chloride 
• 122471-85-6 3-butynyl benzoate 

Downstream Products

• 99058-97-6 3-oxopropyl benzoate 
• 118270-82-9 (2E)-4-acetoxybut-2-en-1-yl benzoate 
• 118270-83-0 Benzoic acid (Z)-4-acetoxy-but-2-enyl ester 
• 118270-78-3 Benzoic acid 3-acetoxy-but-3-enyl ester 
• 118270-61-4 Benzoic acid 3-acetoxy-4-phenylselanyl-butyl ester 
• 118270-62-5 Benzoic acid 4-acetoxy-3-phenylselanyl-butyl ester 
• 245408-81-5 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone 
• 117388-09-7 2-(2,2-difluorocyclopropyl)ethyl benzoate 
• 928201-60-9 benzoic acid 3-(phenyl-triethylsilanyloxy-methyl)-but-3-enyl ester 
• 111860-80-1 Benzoic acid 3-chloro-but-3-enyl ester 
• 1025728-77-1 (E)-5-tosylpent-3-enyl benzoate 
• 1025728-74-8 (Z)-4-cyanobut-3-enyl benzoate 
• 1025728-70-4 (E)-5-methoxy-5-oxopent-3-enyl benzoate 

Relevant academic research and scientific papers

Intermolecular Trifluoromethyl-Hydrazination of Alkenes Enabled by Organic Photoredox Catalysis

A metal-free and redox-neutral trifluoromethyl-hydrazination method of alkenes is described. With a commercially available photocatalyst and low-cost reagents, both conjugated and isolated alkenes could be converted to β-trifluoromethyl hydrazines in good

Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols

An alcohol-directed, nickel-catalyzed three-component umpolung carboamination of unactivated alkenes with aryl/alkenylboronic esters and electrophilic aminating reagents is reported. This transformation is enabled by specifically tailored O-(2,6-dimethoxybenzoyl)hydroxylamine electrophiles that suppress competitive processes, including undesired β-hydride elimination and transesterification between the alcohol substrate and electrophile. The reaction delivers the desired 1,2-carboaminated products with generally high regio- and syn-diastereoselectivity and exhibits a broad scope of coupling partners and alkenes, including complex natural products. Various mechanistic experiments and analysis of the stereochemical outcome with a cyclic alkene substrate, as confirmed by X-ray crystallographic analysis, support alcohol-directed syn-insertion of an organonickel(I) species.

Nickel-catalyzed reductive 1,3-diene formation from the cross-coupling of vinyl bromides

Facile construction of 1,3-dienes building upon cross-electrophile coupling of two open-chain vinyl halides is disclosed in this work, showing moderate chemoselectivities between the terminal bromoalkenes and internal vinyl bromides. The present method is mild and tolerates a range of functional groups and can be applied to the total synthesis of a tobacco fragrance solanone.

MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS

Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF

The present invention provides a fluorine-containing triazolopyridine represented by formula (I) and a racemate, R-stereoisomer, S-stereoisomer, pharmaceutically acceptable salt, or mixture thereof. The triazolopyridine can be used as a positive allosteri

Tuning Regioselectivity of Wacker Oxidation in One Catalytic System: Small Change Makes Big Step

A regioselectivity switchable aerobic Wacker-Tsuji oxidation has been developed using catalytic tert-butyl nitrite as a simple organic redox cocatalyst. By solely switching the solvent, either substituted aldehydes or ketones could be prepared under mild

Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoromethylation of Alkenes and Alkynes

Bromotrifluoromethane (CF 3 Br) is a simple, inexpensive and abundant industrial material employed as a trifluoromethylating reagent. However, only limited strategies using CF 3 Br as a fluorine source are reported. Herein, we describe a visible-light-induced hydrotrifluoromethylation of alkenes and alkynes with CF 3 Br. The reaction proceeds under mild conditions with good functional group tolerance, providing a new route for the application of BrCF 3 in organic synthesis.

Graphene Oxide: An Efficient Acid Catalyst for the Construction of Esters from Acids and Alcohols

Graphene oxide was found to be an efficient and reusable acid catalyst for the esterification reaction. A wide range of aliphatic and aromatic acids and alcohols were compatible with the standard conditions and afforded the corresponding products in good yields. The heterogeneous catalyst can be easily recovered and recycled in dichloro-ethane solvent with good catalytic activity.

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.