Technology Process of (E)-5-phenyl-1-(trimethylsilyl)pent-1-en-3-ol
There total 10 articles about (E)-5-phenyl-1-(trimethylsilyl)pent-1-en-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-phenyl-1-trimethylsilylpent-1-yn-3-ol;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
DOI:10.1021/ol101114r
- Guidance literature:
-
trimethylsilyltributyltin; acetylene;
With
1,1,3,3-tetramethylbutane isonitrile;
palladium diacetate;
In
toluene;
at 35 ℃;
for 24h;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
3-phenyl-propionaldehyde;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Title compound not separated from byproducts;
DOI:10.1055/s-2004-822405
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium sulfate / dichloromethane / 72 h / 20 °C / Inert atmosphere
2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; hexane / 5.25 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: dihydrogen peroxide; sodium hydroxide / Inert atmosphere
With
N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; sec.-butyllithium; magnesium sulfate; sodium hydroxide;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1039/c2ob06975j
