3,4,5-trimethoxy-N-methylaniline

Base Information

• Chemical Name: 3,4,5-trimethoxy-N-methylaniline
• CAS No.: 124346-71-0
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.234
• DSSTox Substance ID: DTXSID40560830
• Wikidata: Q82444432
• Mol file: 124346-71-0.mol

Synonyms:3,4,5-trimethoxy-N-methylaniline;124346-71-0;Benzenamine, 3,4,5-trimethoxy-N-methyl-;SCHEMBL2097204;DTXSID40560830;XBSMHLZMLQNTLY-UHFFFAOYSA-N;N-methyl-3,4,5-trimethoxyaniline;AKOS000250802;EN300-85437;Z335258860

Chemical Property of 3,4,5-trimethoxy-N-methylaniline

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 197.10519334
• Heavy Atom Count: 14
• Complexity: 151

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC(=C(C(=C1)OC)OC)OC

Technology Process of 3,4,5-trimethoxy-N-methylaniline

There total 8 articles about 3,4,5-trimethoxy-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(3,4,5-trimethoxy)phenylformamide (38951-44-9) → N-methyl-3,4,5-trimethoxyaniline (124346-71-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) RT, 2 h;

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,4,5-Trimethoxyaniline (24313-88-0) → N-methyl-3,4,5-trimethoxyaniline (124346-71-0)

Guidance literature:

formaldehyd; 3,4,5-Trimethoxyaniline; In ethanol; at 20 ℃; for 0.0333333h; Inert atmosphere;

With sodium methylate; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

With sodium tetrahydroborate; ethanol; at 0 - 80 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03172

Reference yield: 38.0%

3,4,5-Trimethoxyaniline (24313-88-0) + methyl iodide (74-88-4) → N-methyl-3,4,5-trimethoxyaniline (124346-71-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; for 120h; Ambient temperature;

DOI:10.1021/jm9606913

upstream raw materials:

N-(3,4,5-trimethoxy)phenylformamide

3,4,5-Trimethoxyaniline

methyl iodide

trimethyl orthoformate

Downstream raw materials:

N-(6-Bromo-2-(2,2-dimethyl-propionylamino)-5-{[methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-thieno[2,3-d]pyrimidin-4-yl)-2,2-dimethyl-propionamide

N,N′-{6-[(3,4,5-trimethoxyphenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

C₁₇H₂₀N₆O₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 124346-71-0 Benzenamine, 3,4,5-trimethoxy-N-methyl-

Send

Send

Metric Ton KG G Pound L ML

Send

Send