(1,1-Difluoroethoxy)benzene

Base Information

Chemical Name:(1,1-Difluoroethoxy)benzene
CAS No.:124382-13-4
Molecular Formula:C8H8F2O
Molecular Weight:158.148
Hs Code.:
ChEMBL ID:CHEMBL4646824
DSSTox Substance ID:DTXSID60561485
Wikidata:Q82445320
Mol file:124382-13-4.mol

Synonyms:(1,1-difluoroethoxy)benzene;124382-13-4;1,1-difluoro-ethoxy-benzene;SCHEMBL9770338;CHEMBL4646824;DTXSID60561485;ZTJPNSKFLHWLON-UHFFFAOYSA-N

Suppliers and Price of (1,1-Difluoroethoxy)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (1,1-Difluoroethoxy)benzene

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:158.05432120
Heavy Atom Count:11
Complexity:119

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(OC1=CC=CC=C1)(F)F

Technology Process of (1,1-Difluoroethoxy)benzene

There total 3 articles about (1,1-Difluoroethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 4279-76-9
phenoxyacetylene

: 124382-13-4
1,1-difluoroethyl phenyl ether

Guidance literature:: With pyridine hydrogenfluoride; In dichloromethane; at -78 - 20 ℃; for 18h;
DOI:10.1039/c7ob02987j

Reference yield: 23.0%

: 98-86-2
acetophenone

: 124382-13-4
1,1-difluoroethyl phenyl ether

Guidance literature:: With xenon difluoride; hydrogen fluoride; In dichloromethane; for 24h; Ambient temperature; rearrangement of var. arylsubst. ketones;
DOI:10.1021/jo00290a054

Reference yield:

: 60785-20-8
α,β-dichlorovinyl phenyl ether

: 124382-13-4
1,1-difluoroethyl phenyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / diethyl ether / 4 h / -78 - -40 °C

2: pyridine hydrogenfluoride / dichloromethane / 18 h / -78 - 20 °C

With n-butyllithium; pyridine hydrogenfluoride; In diethyl ether; dichloromethane;
DOI:10.1039/c7ob02987j