Technology Process of 3,4-diethyl-3-(4'-nitrophenyl)-4-(4''-methoxyphenyl)hexane
There total 7 articles about 3,4-diethyl-3-(4'-nitrophenyl)-4-(4''-methoxyphenyl)hexane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) Mg / 1) THF, 0.5 h, 2) 0.5 h
2: 1) HBr, 2) Zn / 1) AcOH, 0 deg C, 1.5 h, 2) 5 deg C -> room temp.
3: 30 percent / nitric acid / acetic anhydride / 2 h / Ambient temperature
4: 50 percent / hydrazine monohydrate / Pd/C / ethanol / 0.33 h / Heating
5: boron trifluoride etherate, tert-butyl nitrite / diethyl ether / 1) -15 deg C, 10 min, 2) 0 deg C, 20 min
6: 1.5 h / Heating
With
tert.-butylnitrite; boron trifluoride diethyl etherate; hydrogen bromide; nitric acid; hydrazine hydrate; magnesium; zinc;
palladium on activated charcoal;
In
diethyl ether; ethanol; acetic anhydride;
DOI:10.1021/jo00302a017
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) HBr, 2) Zn / 1) AcOH, 0 deg C, 1.5 h, 2) 5 deg C -> room temp.
2: 30 percent / nitric acid / acetic anhydride / 2 h / Ambient temperature
3: 50 percent / hydrazine monohydrate / Pd/C / ethanol / 0.33 h / Heating
4: boron trifluoride etherate, tert-butyl nitrite / diethyl ether / 1) -15 deg C, 10 min, 2) 0 deg C, 20 min
5: 1.5 h / Heating
With
tert.-butylnitrite; boron trifluoride diethyl etherate; hydrogen bromide; nitric acid; hydrazine hydrate; zinc;
palladium on activated charcoal;
In
diethyl ether; ethanol; acetic anhydride;
DOI:10.1021/jo00302a017
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 30 percent / nitric acid / acetic anhydride / 2 h / Ambient temperature
2: 50 percent / hydrazine monohydrate / Pd/C / ethanol / 0.33 h / Heating
3: boron trifluoride etherate, tert-butyl nitrite / diethyl ether / 1) -15 deg C, 10 min, 2) 0 deg C, 20 min
4: 1.5 h / Heating
With
tert.-butylnitrite; boron trifluoride diethyl etherate; nitric acid; hydrazine hydrate;
palladium on activated charcoal;
In
diethyl ether; ethanol; acetic anhydride;
DOI:10.1021/jo00302a017
