2-hydroxy-1-thiocyanatoindane

Base Information

• Chemical Name: 2-hydroxy-1-thiocyanatoindane
• CAS No.: 78508-40-4
• Molecular Formula: C₁₀H₉NOS
• Molecular Weight: 191.254
• Mol file: 78508-40-4.mol

Synonyms:

Chemical Property of 2-hydroxy-1-thiocyanatoindane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-1-thiocyanatoindane

There total 2 articles about 2-hydroxy-1-thiocyanatoindane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,3-epoxyindene (768-22-9) + Triphenylphosphin, Thiocyansaeure → 2-hydroxy-1-thiocyanatoindane (78508-40-4)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 4 h, 2.) room temperature;

DOI:10.1039/P19810001577

Reference yield:

1-indene (95-13-6) → 2-hydroxy-1-thiocyanatoindane (78508-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-bromosuccinimide, 2.) 13N potassium hydroxide / 1.) water, room temperature

2: 69 percent / CH₂Cl₂ / 1.) -40 deg C, 4 h, 2.) room temperature

With potassium hydroxide; N-Bromosuccinimide; In dichloromethane;

DOI:10.1039/P19810001577

Reference yield: 73.0%

benzoyl chloride (98-88-4) + 2-hydroxy-1-thiocyanatoindane (78508-40-4) → Benzoic acid (1S,2S)-1-thiocyanato-indan-2-yl ester (78508-42-6)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1039/P19810001577

upstream raw materials:

2,3-epoxyindene

1-indene

Downstream raw materials:

Benzoic acid (1S,2S)-1-thiocyanato-indan-2-yl ester

Refernces