4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide
CAS No.:1011244-72-6
Molecular Formula:C₁₄H₁₁F₃N₂O
Molecular Weight:280.249
Hs Code.:2924297099
European Community (EC) Number:824-254-4
ChEMBL ID:CHEMBL261598
Mol file:1011244-72-6.mol

Synonyms:1011244-72-6;4-Amino-N-(4-trifluoromethylphenyl)benzamide;4-AMINO-N-[4-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE;Teriflunomide impurity 3;CHEMBL261598;BDBM50376394;MFCD09802491;AKOS000152903;HY-134753;CS-0148567;G13577

Suppliers and Price of 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide
50mg
$ 195.00

ChemScene
Teriflunomideimpurity3 99.87%
25mg
$ 170.00

ChemScene
Teriflunomideimpurity3 99.87%
100mg
$ 450.00

ChemScene
Teriflunomideimpurity3 99.87%
50mg
$ 280.00

Acrotein
4-Amino-N-(4-trifluoromethylphenyl)benzamide 97%
0.25g
$ 256.67

Total 7 raw suppliers

Chemical Property of 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

Chemical Property:

Boiling Point:327.6±42.0 °C(Predicted)
PKA:13?+-.0.70(Predicted)
Density:1.373±0.06 g/cm3(Predicted)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:280.08234746
Heavy Atom Count:20
Complexity:330

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F)N
Uses 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide is used to study COX-1 inhibitor, as a potentail analgesics that do not cause gastric damage.

Technology Process of 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

There total 4 articles about 4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1011244-72-6
4-Amino-N-(4-trifluoromethyl-phenyl)-benzamide

Guidance literature:

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 1011244-72-6
4-Amino-N-(4-trifluoromethyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.08 h / Ambient temperature

2: Sn, 6 N HCl / tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; tin; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00153a018

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 1011244-72-6
4-Amino-N-(4-trifluoromethyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.08 h / Ambient temperature

2: Sn, 6 N HCl / tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; tin; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00153a018