N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Base Information

• Chemical Name: N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester
• CAS No.: 864531-12-4
• Molecular Formula: C₆₆H₁₀₄N₄O₁₁
• Molecular Weight: 1129.57
• Mol file: 864531-12-4.mol

Synonyms:

Chemical Property of N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

There total 4 articles about N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

octadec-2t-enoyl chloride (150989-02-9) + tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate (778591-23-4) → N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester (864531-12-4)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1016/j.bmcl.2005.05.114

Reference yield:

(E)-2-octadecenoic acid (2825-79-8) → N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester (864531-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Heating

2: 80 percent / CH₂Cl₂ / 1 h / Heating

With thionyl chloride; In dichloromethane;

DOI:10.1016/j.bmcl.2005.05.114

Reference yield:

Nα-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine (198217-06-0) → N-[3-(benzoyloxy-octadec-2-enoyl-amino)-propyl]-2-{[3-(benzoyloxy-octadec-2-enoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester (864531-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCl

2.1: HOSu; DCC / dioxane

2.2: TEA / acetonitrile

3.1: 80 percent / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2005.05.114

upstream raw materials:

octadec-2t-enoyl chloride

tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

(E)-2-octadecenoic acid

N^α-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine