2825-79-8Relevant articles and documents
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Palameta,B.,Prostenik,M.
, p. 1463 - 1470 (1963)
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Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase
Wiemann, Jana,Karasch, Julia,Loesche, Anne,Heller, Lucie,Brandt, Wolfgang,Csuk, René
, p. 222 - 231 (2017/08/14)
Piperlongumine B (19), an alkaloid previously isolated from long pepper (Piper longum) has been synthesized for the first time in a short sequence and in good yield together with 19 analogs. Screening of these compounds in Ellman's assays showed several of them to be good inhibitors of acetylcholinesterase while being less active for butyrylcholinesterase. Activity of the compounds increased with the ring size of the heterocycle, and a maximum of activity was observed for an analog holding 12 methylene groups in the aliphatic side chain. These compounds may be regarded as promising candidates for the development of efficient inhibitors of acetylcholinesterase being useful for the treatment of Alzheimer's disease.
(Z) 1'-propylbutyl 3-octadecenoate from Fagara budrunga fruits
Naik,Katke, Sujata,Banhatti, Padmini,Natu
, p. 122 - 124 (2007/10/03)
Chemical constituents of the Indian medicinal plant Fagara budrunga commonly known as mullilam, have been isolated. In addition to the known compounds a new ester has been obtained. It has been assigned the structure (Z) 1'-propylbutyl 3-octadecenoate 1 from chemical conversions and spectral analysis.