2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)-

Base Information

Chemical Name:2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)-
CAS No.:124955-27-7
Molecular Formula:C19H19NO6
Molecular Weight:357.363
Hs Code.:
Mol file:124955-27-7.mol

Synonyms:6-benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one;

Suppliers and Price of 2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)-

Chemical Property:

PSA：94.09000
LogP:2.27210

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)-

There total 1 articles about 2H-1,4-Benzoxazin-3(4H)-one, 8-(ethoxyhydroxyacetyl)-6-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 693273-07-3
6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

: 64-17-5
ethanol

: 124955-27-7
8-(2-hydroxy-2-ethoxyacetyl)-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one

Guidance literature:: for 2h; Reflux;
DOI:10.1016/j.bmcl.2009.12.087

Reference yield: 74.0%

: 124955-27-7
8-(2-hydroxy-2-ethoxyacetyl)-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one

: 861842-18-4
1-{3-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-2-hydroxy-ethylamino]-3-methyl-butyl}-4,4-dipropyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride

Guidance literature:: 1-(3-amino-3-methyl-butyl)-4,4-dipropyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride salt; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

8-(2-hydroxy-2-ethoxyacetyl)-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; lithium borohydride; water; more than 3 stages;

Reference yield: 74.0%

: 124955-27-7
8-(2-hydroxy-2-ethoxyacetyl)-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one

: 861842-02-6
1-(3-amino-3-methyl-butyl)-4,4-dipropyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride salt

: 861842-18-4
1-{3-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-2-hydroxy-ethylamino]-3-methyl-butyl}-4,4-dipropyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride

Guidance literature:: 8-(2-hydroxy-2-ethoxyacetyl)-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one; 1-(3-amino-3-methyl-butyl)-4,4-dipropyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one hydrochloride salt; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2.5h;

With lithium borohydride; In tetrahydrofuran; at 10 - 20 ℃; for 1h;

With hydrogenchloride; water; more than 3 stages;