5'-DMTr-2-thio-thyMidine

Base Information

Chemical Name:5'-DMTr-2-thio-thyMidine
CAS No.:125258-60-8
Molecular Formula:C31H32N2O6S
Molecular Weight:560.671
Hs Code.:
Mol file:125258-60-8.mol

Synonyms:1-(2'-deoxy-5'-O-4,4'-dimethoxytrityI-β-D-erythro-ribofuranosyl)-2-thiothymine;5'-DMTr-2-thio-thymidine;

Suppliers and Price of 5'-DMTr-2-thio-thyMidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 95+%
100mg
$ 400.00

Chemenu
1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 95%
100mg
$ 374.00

Total 7 raw suppliers

Chemical Property of 5'-DMTr-2-thio-thyMidine

Chemical Property:

PSA：127.03000
LogP:4.88860

Purity/Quality:

97% ^*data from raw suppliers

1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5'-DMTr-2-thio-thyMidine

There total 5 articles about 5'-DMTr-2-thio-thyMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 28585-51-5
2-thiothymidine

: 125258-60-8
1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃;

Reference yield: 85.0%

: 4,4-dimethoxytrityl chloride

: 28585-51-5
2-thiothymidine

: 125258-60-8
1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: 4,4-dimethoxytrityl chloride; 2-thiothymidine; With dmap; In pyriidine; at 0 - 20 ℃; for 6h;

With methanol; In pyridine;

Reference yield:

: 4-Methyl-benzoic acid (1R,10R,11S)-4-methyl-5-oxo-8,13-dioxa-2,6-diaza-tricyclo[8.2.1.0^2,7]trideca-3,6-dien-11-yl ester

: 125258-60-8
1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂S (liquid), pyridine

2: 0.1 M NaOMe

3: pyridine, DMAP

With pyridine; dmap; hydrogen sulfide; sodium methylate;
DOI:10.1016/S0040-4039(00)79235-5