1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

Base Information

Chemical Name:1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine
CAS No.:1213779-12-4
Molecular Formula:C₃₂H₃₄N₂O₆S
Molecular Weight:574.698
Hs Code.:

Synonyms:1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

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Chemical Property of 1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

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Technology Process of 1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

There total 3 articles about 1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 125258-60-8
1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

: 74-88-4
methyl iodide

: 1213779-12-4
1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 1h;
DOI:10.1039/d0cc07922g

Reference yield:

: 28585-51-5
2-thiothymidine

: 1213779-12-4
1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / methanol / 12 h / 25 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1021/acschembio.7b00108

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1213779-12-4
1-(2'-deoxy-5'-O-4,4'-dimethoxytrityl-β-D-erythro-ribofuranosyl)-2-methylthiothymine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / methanol / 12 h / 25 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1021/acschembio.7b00108