(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Base Information

Chemical Name:(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide
CAS No.:1367877-55-1
Molecular Formula:C₂₇H₂₈F₄N₂O₄S
Molecular Weight:552.59
Hs Code.:

(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Synonyms:

Suppliers and Price of (3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

There total 11 articles about (3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 661-54-1
3,3,3-trifluoroprop-1-yne

: 1204343-71-4
(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-iodo-benzyl)-3-(3-tert-butyl-benzyl)-hexahydro-2H-thiopyrano[3,4-d]xazol-2-one 5,5-dioxide

: 1367877-55-1
(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Guidance literature:: 3,3,3-trifluoroprop-1-yne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; at 25 ℃; for 1h; Inert atmosphere;

(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-iodo-benzyl)-3-(3-tert-butyl-benzyl)-hexahydro-2H-thiopyrano[3,4-d]xazol-2-one 5,5-dioxide; In tetrahydrofuran; diethyl ether; hexane; at 60 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm300069y

Reference yield:

: 1367877-38-0
(3aR,7S,7aS)-3-(3-(tert-butyl)benzyl)-7-(3-fluoro-4-nitrobenzyl)hexahydro-2H-thiopyrano-[3,4d]oxazol-2-one 5,5-dioxide

: 1367877-55-1
(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h

2.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / methanol; chloroform / 16 h / 60 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / 25 °C / Inert atmosphere

3.3: 18 h / 60 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In tetrahydrofuran; methanol; hexane; chloroform;
DOI:10.1021/jm300069y

Reference yield:

: 1367876-83-2
tert-butyl ((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)carbamate

: 1367877-55-1
(3aR,7S,7aS)-7-(4-amino-3-fluoro-5-(3,3,3-trifluoroprop-1-yn-1-yl)benzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 25 - 40 °C / Inert atmosphere

2.1: sodium acetate / methanol; dichloromethane / 0.5 h / 25 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

2.3: 0.25 h / Inert atmosphere

3.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h

5.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / methanol; chloroform / 16 h / 60 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

6.2: 1 h / 25 °C / Inert atmosphere

6.3: 18 h / 60 °C / Inert atmosphere

With hydrogenchloride; dmap; n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium acetate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; N-ethyl-N,N-diisopropylamine; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jm300069y