{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Base Information

• Chemical Name: {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester
• CAS No.: 173961-43-8
• Molecular Formula: C₄₂H₄₉N₅O₁₂
• Molecular Weight: 815.877
• Mol file: 173961-43-8.mol

Synonyms:

Chemical Property of {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

There total 11 articles about {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine (130515-58-1) → {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-43-8)

Guidance literature:

Multi-step reaction with 8 steps

1: NH₄OH

2: pyridine

3: NH₄OH / 48 h / 55 °C

4: pyridine

5: AcOH / Ambient temperature

6: pyridine

7: pyridine

8: NH₄OH

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

Reference yield:

Methanesulfonic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-35-8) → {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-43-8)

Guidance literature:

Multi-step reaction with 7 steps

1: pyridine

2: NH₄OH / 48 h / 55 °C

3: pyridine

4: AcOH / Ambient temperature

5: pyridine

6: pyridine

7: NH₄OH

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

Reference yield:

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9) → {(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-43-8)

Guidance literature:

Multi-step reaction with 6 steps

1: NH₄OH / 48 h / 55 °C

2: pyridine

3: AcOH / Ambient temperature

4: pyridine

5: pyridine

6: NH₄OH

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

upstream raw materials:

Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

4,4'-dimethoxytrityl chloride

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

Acetic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester