Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Base Information

• Chemical Name: Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester
• CAS No.: 173961-36-9
• Molecular Formula: C₃₂H₃₆N₂O₉S
• Molecular Weight: 624.712
• Mol file: 173961-36-9.mol

Synonyms:

Chemical Property of Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

There total 9 articles about Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine (130515-58-1) → Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OH

2: pyridine

With pyridine; ammonium hydroxide;

DOI:10.1080/15257779508010708

Reference yield:

2',3'-O,O-isopropylidene-5-methyluridine (2073-43-0) → Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9)

Guidance literature:

Multi-step reaction with 9 steps

1: pyridine / 5 h / 15 °C / Large scale

2: water; trifluoroacetic acid / 10 h / 15 °C / Large scale

3: sodium periodate / ethanol; water / 2 h / 15 °C / Darkness

4: water; sodium tetrahydroborate; ethanol / 1 h / 0 - 15 °C

5: triethylamine / dichloromethane / 4 h / 0 °C

6: hydrogen iodide / N,N-dimethyl-formamide / 0.5 h / 15 °C

7: sodium acetate; hydrogen; palladium on activated charcoal / ethanol / 10 h / 15 °C / 775.74 Torr

8: ammonium hydroxide / methanol / 16 h / 15 °C

9: pyridine / 4 h / 15 °C

With pyridine; ammonium hydroxide; sodium tetrahydroborate; sodium periodate; ethanol; palladium on activated charcoal; water; hydrogen iodide; hydrogen; sodium acetate; triethylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

1-(5-O-benzoyl-β-D-ribofuranosyl)thymine (120649-55-0) → Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium periodate / ethanol; water / 2 h / 15 °C / Darkness

2: water; sodium tetrahydroborate; ethanol / 1 h / 0 - 15 °C

3: triethylamine / dichloromethane / 4 h / 0 °C

4: hydrogen iodide / N,N-dimethyl-formamide / 0.5 h / 15 °C

5: sodium acetate; hydrogen; palladium on activated charcoal / ethanol / 10 h / 15 °C / 775.74 Torr

6: ammonium hydroxide / methanol / 16 h / 15 °C

7: pyridine / 4 h / 15 °C

With pyridine; ammonium hydroxide; sodium tetrahydroborate; sodium periodate; ethanol; palladium on activated charcoal; water; hydrogen iodide; hydrogen; sodium acetate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

5-Methyluridine

2',3'-O,O-isopropylidene-5-methyluridine

5'-O-benzoyl-2',3'-O-isopropylidene-5-methyluridine

Downstream raw materials:

1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

1-((R)-1-{(S)-1-Aminomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione