Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Base Information

• Chemical Name: Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester
• CAS No.: 173961-42-7
• Molecular Formula: C₄₄H₅₁N₅O₁₃
• Molecular Weight: 857.915
• Mol file: 173961-42-7.mol

Synonyms:

Chemical Property of Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

There total 9 articles about Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine (130515-58-1) → Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-42-7)

Guidance literature:

Multi-step reaction with 7 steps

1: NH₄OH

2: pyridine

3: NH₄OH / 48 h / 55 °C

4: pyridine

5: AcOH / Ambient temperature

6: pyridine

7: pyridine

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

Reference yield:

Methanesulfonic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-35-8) → Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-42-7)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine

2: NH₄OH / 48 h / 55 °C

3: pyridine

4: AcOH / Ambient temperature

5: pyridine

6: pyridine

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

Reference yield:

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9) → Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-42-7)

Guidance literature:

Multi-step reaction with 5 steps

1: NH₄OH / 48 h / 55 °C

2: pyridine

3: AcOH / Ambient temperature

4: pyridine

5: pyridine

With pyridine; ammonium hydroxide; acetic acid;

DOI:10.1080/15257779508010708

upstream raw materials:

Acetic acid (S)-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-3-(4-nitro-phenoxycarbonyloxy)-propyl ester

1-((R)-1-{(S)-1-Aminomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

4,4'-dimethoxytrityl chloride

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

Downstream raw materials:

{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester