Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-

Base Information

• Chemical Name: Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-
• CAS No.: 126070-20-0
• Molecular Formula: C13H22O2Si
• Molecular Weight: 238.402
• DSSTox Substance ID: DTXSID70459480
• Nikkaji Number: J1.090.230D
• Mol file: 126070-20-0.mol

Synonyms:126070-20-0;4-(((tert-butyldimethylsilyl)oxy)methyl)phenol;Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-;4-[[tert-butyl(dimethyl)silyl]oxymethyl]phenol;4-(((t-butyldimethylsilyl)oxy)methyl)phenol;4-{[(TERT-BUTYLDIMETHYLSILYL)OXY]METHYL}PHENOL;SCHEMBL906834;DTXSID70459480;OXNXETVAZHYQFN-UHFFFAOYSA-N;BFA07020;MFCD29042407;4-Tert-butyldimethylsiloxymethylphenol;4-(tert-Butyldimethylsiloxymethyl)phenol;AS-55039;-4tert-butyldimethylsilyl)oxy)methyl)phenol;4-((tert-butyldimethylsilyloxy)methyl)phenol;CS-0035842;W12748

Chemical Property of Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-

Chemical Property:

• PSA: 29.46000
• LogP: 3.91400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 238.138906475
• Heavy Atom Count: 16
• Complexity: 213

Purity/Quality:

98%min ^*data from raw suppliers

4-(((Tert-Butyldimethylsilyl)Oxy)Methyl)Phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCC1=CC=C(C=C1)O

Technology Process of Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-

There total 17 articles about Phenol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-hydroxyphenyl)methanol (623-05-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-((tert-butyldimethylsilyloxy)methyl)phenol (126070-20-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

Reference yield: 99.0%

tert-butyl(4-(iso-propoxydimethylsilyl)benzyloxy)dimethylsilane (1228447-97-9) → 4-((tert-butyldimethylsilyloxy)methyl)phenol (126070-20-0)

Guidance literature:

With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b924135c

Reference yield: 98.0%

1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene (117635-46-8) → 4-((tert-butyldimethylsilyloxy)methyl)phenol (126070-20-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; acetonitrile; at 60 ℃; for 5h;

DOI:10.1055/s-2006-958425

upstream raw materials:

1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene

(4-hydroxyphenyl)methanol

tert-butyldimethylsilyl chloride

1H-imidazole

Downstream raw materials:

4-(hydroxymethyl)phenyl isobutyrate

4-hydroxy-benzaldehyde

2-[4-(tert-butyldimethylsiloxymethyl)phenoxymethyl]-5-methoxy-1,3-dimethylindole-4,7-dione

3-[4-(tert-butyldimethylsiloxymethyl)phenoxymethyl]-5-methoxy-1,2-dimethylindole-4,7-dione