{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

Base Information

Chemical Name:{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester
CAS No.:290836-21-4
Molecular Formula:C₄₅H₇₄N₄O₁₂
Molecular Weight:863.102
Hs Code.:

{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

Synonyms:

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Chemical Property of {[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

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Technology Process of {[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

There total 1 articles about {[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: (1S,2S)-N-[(S)-2-Amino-3-(4-nitro-phenyl)-propyl]-cyclohexane-1,2-diamine; hydrochloride

: 290836-21-4
{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1016/S0968-0896(97)00130-2

Reference yield:

: 290836-21-4
{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

: 133775-66-3,1105741-38-5
{[(S)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: TFA

2: H₂, Na₂CO₃ / 10percent Pd/C / H₂O

With hydrogen; sodium carbonate; trifluoroacetic acid; palladium on activated charcoal; In water;
DOI:10.1016/S0968-0896(97)00130-2

Reference yield:

: 290836-21-4
{[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester

: 157380-45-5
{[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(S)-2-(bis-carboxymethyl-amino)-3-(4-isothiocyanato-phenyl)-propyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: TFA

2: H₂, Na₂CO₃ / 10percent Pd/C / H₂O

3: H₂O; CHCl₃ / 2 h

With hydrogen; sodium carbonate; trifluoroacetic acid; palladium on activated charcoal; In chloroform; water;
DOI:10.1016/S0968-0896(97)00130-2