157380-45-5

Basic information

• Product Name: CHX-A''-DTPA(B-355)
• Synonyms: CHX-A''-DTPA(B-355)
• CAS NO: 157380-45-5
• Molecular Formula: C26H34N4O10S
• Molecular Weight: 594.63
• Mol File: 157380-45-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CHX-A''-DTPA(B-355)(CAS DataBase Reference)
• NIST Chemistry Reference: CHX-A''-DTPA(B-355)(157380-45-5)
• EPA Substance Registry System: CHX-A''-DTPA(B-355)(157380-45-5)

Safety Data

• Hazardous Substances Data: 157380-45-5(Hazardous Substances Data)

Usage

Uses

p-SCN-Bn-CHX-A”-DTPA is a novel bifunctional maleimido CHX-A'''' chelator for conjugation to thiol-containing biomolecules such as trastuzumab and binding to ovarian cancer cells.

Upstream product

• 463-71-8 thiophosgene 
• 133725-78-7 N-[2-amino-3-(p-aminophenyl)propyl]-trans-cyclohexane-1,2-diamine-N,N',N',N,N-pentaacetic acid 
• 88319-56-6 N-tert-butoxycarbonyl-p-nitrophenylalanine N-hydroxysuccinimidyl ester 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 133725-76-5 (1R,2R)-N-[2-Amino-3-(4-nitro-phenyl)-propyl]-cyclohexane-1,2-diamine 
• 133725-75-4 N-tert-butoxycarbonyl-N'-(trans-2-aminocyclohexyl)-p-nitrophenylalaninamide 
• 133725-77-6 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 133725-78-7 N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 86937-80-6 2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid 
• 142350-84-3 2-Amino-N-((1S,2S)-2-amino-cyclohexyl)-3-(4-nitro-phenyl)-propionamide; hydrochloride 
• 133725-77-6 N-[2-amino-3-(p-nitrophenyl)propyl]-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133725-78-7 N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133725-77-6 N-[2-amino-3-(p-nitrophenyl)propyl]-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 133775-66-3 {[(S)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 

Relevant articles and documents

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

An Effective Chelating Agent for Labelling of Monoclonal Antibody with 212Bi for &α-Particle Mediated Radioimmunotherapy

The ligand N--(+/-)trans-1,2-diaminocyclohexane-N,N',N''-pentaacetic acid has been synthesized and linked to lgG and to monoclonal antibody B72.3 and labelled with 206Bi and 212Bi to demonstrate the in vivo stabil