157380-45-5

Usage

Uses

Used in Pharmaceutical Industry:
CHX-A''-DTPA(B-355) is used as a chelating agent for the conjugation of thiol-containing biomolecules, such as trastuzumab, to target ovarian cancer cells. This application is essential in the development of targeted therapies for ovarian cancer, as it enables the selective delivery of drugs to cancer cells, reducing side effects and improving treatment outcomes.
Additionally, CHX-A''-DTPA(B-355) can be utilized in the development of other targeted therapies for various types of cancer, as its chelating properties allow for the conjugation of different biomolecules to specific cancer cell targets. This versatility makes it a valuable compound in the ongoing research and development of novel cancer treatments.

Upstream product

• 133725-77-6 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 86937-80-6 2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid 
• 199480-82-5 {[(1R,2R)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(R)-2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 463-71-8 thiophosgene 
• 1105741-38-5 {[(R)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1R,2R)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 
• 199480-81-4 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(R)-2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 880644-82-6 N-[(R)-2-amino-3-(p-nitrophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate 
• 1105741-38-5 {[(R)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 
• 133775-65-2 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(S)-2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 290836-21-4 {[(1S,2S)-2-(Bis-tert-butoxycarbonylmethyl-amino)-cyclohexyl]-[(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid tert-butyl ester 
• 133775-66-3 {[(S)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 
• 133725-77-6 N-[2-amino-3-(p-nitrophenyl)propyl]-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid 
• 142350-84-3 2-Amino-N-((1S,2S)-2-amino-cyclohexyl)-3-(4-nitro-phenyl)-propionamide; hydrochloride 
• 133725-75-4 N-tert-butoxycarbonyl-N'-(trans-2-aminocyclohexyl)-p-nitrophenylalaninamide 

Relevant academic research and scientific papers

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

Synthesis of C-Functionalized trans-Cyclohexyldiethylenetriaminepenta-acetic Acids for Labelling of Monoclonal Antibodies with the Bismuth-212 α-Particle Emitter

Several C-functionalized cyclohexyldiethylenetriaminepenta-acetic acid derivatives have been prepared from (+/-)-4-nitrophenylalanine and (+/-)-trans-cyclohexane-1,2-diamine to produce two sets of diastereoisomeric enantiomers.A modification of this synth

An Effective Chelating Agent for Labelling of Monoclonal Antibody with 212Bi for &α-Particle Mediated Radioimmunotherapy

The ligand N--(+/-)trans-1,2-diaminocyclohexane-N,N',N''-pentaacetic acid has been synthesized and linked to lgG and to monoclonal antibody B72.3 and labelled with 206Bi and 212Bi to demonstrate the in vivo stabil