C₁₆H₂₂O₂

Base Information

• Chemical Name: C₁₆H₂₂O₂
• CAS No.: 1300655-87-1
• Molecular Formula: C₁₆H₂₂O₂
• Molecular Weight: 246.349
• Mol file: 1300655-87-1.mol

Synonyms:

Chemical Property of C₁₆H₂₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂O₂

There total 4 articles about C₁₆H₂₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

C13H18O2 (1300655-86-0) + prop-1-yne (74-99-7) → C16H22O2 (1300655-87-1)

Guidance literature:

prop-1-yne; With n-butyllithium; In hexane; tert-butyl methyl ether; at -78 ℃; for 0.166667h; Inert atmosphere;

With trimethylaluminum; In hexane; tert-butyl methyl ether; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

C₁₃H₁₈O₂; Further stages;

DOI:10.1021/ja201467z

Reference yield:

(E)-hex-4-en-1-ol (928-92-7) → C16H22O2 (1300655-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 70 °C / Inert atmosphere

2.1: Oxone; Shi's ketone; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; potassium carbonate; acetic acid; potassium hydroxide / Dimethoxymethane; acetonitrile / 3 h / -10 °C / Inert atmosphere; aq. buffer

3.1: n-butyllithium / hexane; tert-butyl methyl ether / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.67 h / 0 - 20 °C / Inert atmosphere

With Oxone; n-butyllithium; Shi's ketone; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; Dimethoxymethane; hexane; tert-butyl methyl ether; acetonitrile;

DOI:10.1021/ja201467z

Reference yield:

benzyl bromide (100-39-0) → C16H22O2 (1300655-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 70 °C / Inert atmosphere

2.1: Oxone; Shi's ketone; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; potassium carbonate; acetic acid; potassium hydroxide / Dimethoxymethane; acetonitrile / 3 h / -10 °C / Inert atmosphere; aq. buffer

3.1: n-butyllithium / hexane; tert-butyl methyl ether / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.67 h / 0 - 20 °C / Inert atmosphere

With Oxone; n-butyllithium; Shi's ketone; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; Dimethoxymethane; hexane; tert-butyl methyl ether; acetonitrile;

DOI:10.1021/ja201467z

upstream raw materials:

C₁₃H₁₈O₂

prop-1-yne

(E)-hex-4-en-1-ol

benzyl bromide

Downstream raw materials:

C₃₁H₅₂O₆Si

C₃₄H₅₆O₈Si

C₄₁H₆₇NO₇S₂Si

C₃₆H₆₀O₈Si