4-HYDROXY-3-FORMYL-6-METHYLCOUMARIN

Base Information

• Chemical Name: 4-HYDROXY-3-FORMYL-6-METHYLCOUMARIN
• CAS No.: 126214-23-1
• Molecular Formula: C11H8O4
• Molecular Weight: 204.17900
• Hs Code.: 2932209090
• Mol file: 126214-23-1.mol

Synonyms:4-HYDROXY-6-METHYL-2-OXO-2H-CHROMENE-3-CARBALDEHYDE;4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde;2H-1-Benzopyran-3-carboxaldehyde,4-hydroxy-6-methyl-2-oxo;

Chemical Property of 4-HYDROXY-3-FORMYL-6-METHYLCOUMARIN

Chemical Property:

• PSA: 67.51000
• LogP: 1.61950

Purity/Quality:

4-Hydroxy-6-methyl-2-oxo-2H-chromene-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-3-FORMYL-6-METHYLCOUMARIN

There total 2 articles about 4-HYDROXY-3-FORMYL-6-METHYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-hydroxy-6-methylcoumarin (13252-83-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde (126214-23-1)

Guidance literature:

With trichlorophosphate; for 9h; Heating;

DOI:10.1002/jhet.5570400231

Reference yield:

6-methyl-4-oxo-4H-chromene-3-carboxylic acid (68723-78-4) → 4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde (126214-23-1)

Guidance literature:

With methanol; sodium hydroxide; sulfuric acid; Yield given. Multistep reaction; 1) 1-3h, reflux, 2) 20 deg C, 15 - 30 min;

Reference yield: 77.0%

4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde (126214-23-1) + acetophenone (98-86-2) → 4-hydroxy-6-methyl-2-oxo-3-(3'-oxo-3'-phenylprop-1'-enyl)-2H-1-benzopyran

Guidance literature:

4-hydroxy-6-methyl-2-oxo-2H-1-benzopyran-3-carboxaldehyde; acetophenone; With sodium hydroxide; In ethanol; for 2h;

In ethanol; for 6h; Heating;

DOI:10.1002/jhet.5570400231

upstream raw materials:

6-methyl-4-oxo-4H-chromene-3-carboxylic acid

4-hydroxy-6-methylcoumarin

N,N-dimethyl-formamide

Downstream raw materials:

8-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-one

4-(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one

4-Hydroxy-6-methyl-3-(5-{[1-phenyl-meth-(E)-ylidene]-amino}-[1,3,4]oxadiazol-2-yl)-chromen-2-one

1-[5-(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)-[1,3,4]oxadiazol-2-yl]-3-phenyl-thiourea