(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

Base Information

Chemical Name:(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester
CAS No.:108782-83-8
Molecular Formula:C₃₇H₃₅N₆O₈PS
Molecular Weight:754.76
Hs Code.:

(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

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Chemical Property of (S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

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Technology Process of (S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

There total 4 articles about (S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75414-47-0
O-(4-nitrophenyl)-N-phenylphosphoramidochloridate

: 108782-83-8
(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 h / Ambient temperature

2: 1.) NaH, 2.) CS₂, Dowex 50 Wx₈ / 1.) dioxane, 15 min, room temp.

3: acetone / 20 h / Ambient temperature

With pyridine; carbon disulfide; DOWEX 50 WX₈; sodium hydride; In acetone;
DOI:10.1016/S0040-4020(01)88054-6

Reference yield:

: 51600-10-3
2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine

: 108782-83-8
(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 h / Ambient temperature

2: 1.) NaH, 2.) CS₂, Dowex 50 Wx₈ / 1.) dioxane, 15 min, room temp.

3: acetone / 20 h / Ambient temperature

With pyridine; carbon disulfide; DOWEX 50 WX₈; sodium hydride; In acetone;
DOI:10.1016/S0040-4020(01)88054-6

Reference yield:

: 99782-06-6
(R)-Phenyl-phosphoramidic acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

: 108782-83-8
(S)-Thiophosphoric acid O-{(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester O'-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) CS₂, Dowex 50 Wx₈ / 1.) dioxane, 15 min, room temp.

2: acetone / 20 h / Ambient temperature

With carbon disulfide; DOWEX 50 WX₈; sodium hydride; In acetone;
DOI:10.1016/S0040-4020(01)88054-6