(2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one

Base Information

Chemical Name:(2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
CAS No.:1638956-59-8
Molecular Formula:C₁₇H₁₄O₅
Molecular Weight:298.295
Hs Code.:
DSSTox Substance ID:DTXSID801157082
Mol file:1638956-59-8.mol

Synonyms:(2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one;1638956-59-8;210360-75-1;(2Z)-2-[(2,5-dimethoxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one;(Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one;MFCD04064399;2-[(2,5-dimethoxyphenyl)methylidene]-6-hydroxy-2,3-dihydro-1-benzofuran-3-one;2-(2,5-Dimethoxybenzylidene)-6-hydroxybenzofuran-3(2h)-one;(2Z)-2-[(2,5-dimethoxyphenyl)methylidene]-6-hydroxy-2,3-dihydro-1-benzofuran-3-one;SCHEMBL6962871;DTXSID801157082;NSC816233;STK923235;AKOS000270921;NSC-816233;LS-05758;EN300-36338;VU0510338-1;F3139-1893;Z196385658;(2Z)-2-[(2,5-Dimethoxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone

Suppliers and Price of (2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(Z)-2-(2,5-Dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one 97%
5g
$ 904.00

Crysdot
(Z)-2-(2,5-Dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one 97%
1g
$ 320.00

Total 1 raw suppliers

Chemical Property of (2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:298.08412354
Heavy Atom Count:22
Complexity:446

Purity/Quality:: (Z)-2-(2,5-Dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)OC)C=C2C(=O)C3=C(O2)C=C(C=C3)O
Isomeric SMILES:COC1=CC(=C(C=C1)OC)/C=C\2/C(=O)C3=C(O2)C=C(C=C3)O

Technology Process of (2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one

There total 3 articles about (2Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6272-26-0
6-hydroxybenzofuran-3-one

: 93-02-7
2,5-dimethoxybenzaldehyde

: 1638956-59-8,210360-75-1
(Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one

Guidance literature:: With hydrogenchloride; In ethanol; water; at 60 - 70 ℃;
DOI:10.1016/j.bmc.2014.11.004

Reference yield:

: 25015-92-3
2-chloro-1-(2,4-dihydroxyphenyl)ethanone

: 1638956-59-8,210360-75-1
(Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 30 - 50 °C

2: sodium hydroxide / water; methanol / 30 - 40 °C

With sodium hydroxide; In methanol; water; 2: |Claisen-Schmidt Condensation;
DOI:10.2174/1573406413666170623085534

Reference yield:

: 108-46-3
recorcinol

: 1638956-59-8,210360-75-1
(Z)-2-(2,5-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / diethyl ether / 0 - 30 °C

2: sodium hydroxide / water / 30 - 50 °C

3: sodium hydroxide / water; methanol / 30 - 40 °C

With aluminum (III) chloride; sodium hydroxide; In methanol; diethyl ether; water; 1: |Friedel-Crafts Acylation / 3: |Claisen-Schmidt Condensation;
DOI:10.2174/1573406413666170623085534