(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

Base Information

Chemical Name:(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide
CAS No.:1350721-74-2
Molecular Formula:C₄₇H₅₆N₈O₅
Molecular Weight:813.012
Hs Code.:

(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

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Chemical Property of (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

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Technology Process of (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

There total 10 articles about (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₅H₅₈N₈O₇

: 1350721-74-2
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

Guidance literature:: C₅₅H₅₈N₈O₇; With hydrazine hydrate; In methanol; at 20 ℃; for 16h;

With potassium hydrogensulfate; at 20 ℃; for 3h;
DOI:10.1002/cmdc.201100241

Reference yield:

: 245753-74-6
C₂₆H₃₂N₂O₃

: 1350721-74-2
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 20 °C

2.1: hydrazine hydrate / methanol / 16 h / 20 °C

2.2: 3 h / 20 °C

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1002/cmdc.201100241

Reference yield:

: 1334182-43-2
(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

: 1350721-74-2
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-(2-{1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl}acetyl)ornithinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 20 °C

3.1: hydrazine hydrate / methanol / 16 h / 20 °C

3.2: 3 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; acetonitrile;
DOI:10.1002/cmdc.201100241