C₃₂H₂₈F₃N₃O₂

Base Information

• Chemical Name: C₃₂H₂₈F₃N₃O₂
• CAS No.: 1093685-65-4
• Molecular Formula: C₃₂H₂₈F₃N₃O₂
• Molecular Weight: 543.588
• Mol file: 1093685-65-4.mol

Synonyms:

Chemical Property of C₃₂H₂₈F₃N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₈F₃N₃O₂

There total 5 articles about C₃₂H₂₈F₃N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester (809273-70-9) → C32H28F3N3O2 (1093685-65-4)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

3: 2,6-dimethylpyridine

4: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With 2,6-dimethylpyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 4: Suzuki cross-coupling;

DOI:10.1016/j.bmcl.2011.02.049

Reference yield:

4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(4-oxocyclohexyl)methyl]benzamide (1093685-27-8) → C32H28F3N3O2 (1093685-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With 2,6-dimethylpyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; 2: Suzuki cross-coupling;

DOI:10.1016/j.bmcl.2011.02.049

Reference yield:

4-Aminomethyl-cyclohexanone (934475-93-1) → C32H28F3N3O2 (1093685-65-4)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

2: 2,6-dimethylpyridine

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With 2,6-dimethylpyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 3: Suzuki cross-coupling;

DOI:10.1016/j.bmcl.2011.02.049

upstream raw materials:

(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester

4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(4-oxocyclohexyl)methyl]benzamide

4-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

(meta-(trifluoromethyl)phenyl)boronic acid